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(1) Cereais temperados (1) Controle biológico (1) Controle integrado (1) Disease (1) Disease index (1) Mais... Tipo do documento Comunicado Técnico (INFOTECA-E) (4) Info:eu-repo/semantics/article (3) Boletim de Pesquisa e Desenvolvimento (INFOTECA-E) (2) Circular Técnica (INFOTECA-E) (1) Pesquisa Empírica de Campo (1) Ano 2021 (1) 2020 (2) 2018 (1) 2016 (4) 2015 (1) 2012 (1) 2011 (1) Mais... País Brazil (11) Idioma Português (6) Inglês (4) Espanhol (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 143 Primeira ... 1 2 3 4 5 6 7 8 ... Última Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis Biol. Res. RUBBO,HOMERO; BATTHYANY,CARLOS; RADI,RAFAEL. Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the ‘oxidative-modification hypothesis,’ which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (.NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e.: peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and .NO and cellular sites... Tipo: Journal article Palavras-chave: Antioxidants; Free radicals; Lipid oxidation; Low density lipoprotein oxidation; Nitric oxide; Peroxynitrite. Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017 Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress BJMBR Pertrini,C.M.; Miyakawa,A.A.; Laurindo,F.R.M.; Krieger,J.E.. Mechanical forces including pressure and shear stress play an important role in vascular homeostasis via the control of the production and release of a variety of vasoactive factors. An increase in vascular shear stress is accompanied by nitric oxide (NO) release and NO synthase activation. Previously, we have demonstrated that shear stress induces angiotensin-I converting enzyme (ACE) down-regulation in vivo and in vitro. In the present study, we determined whether NO participates in the shear stress-induced ACE suppression response. Rabbit aortic endothelial cells were evaluated using the NO synthase inhibitor L-NAME, and two NO donors, diethylamine NONOate (DEA/NO) and sodium nitroprusside (SNP). Under static conditions, incubation of endothelial cells... Tipo: Info:eu-repo/semantics/other Palavras-chave: Shear stress; Angiotensin-I converting enzyme; Nitric oxide; Endothelial cells. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900005 Nitric oxide release from the S-nitrosothiol zinc phthalocyanine complex by flash photolysis BJMBR Rotta,J.C.G.; Lunardi,C.N.; Tedesco,A.C.. The photogeneration of nitric oxide (NO) using laser flash photolysis was investigated for S-nitroso-glutathione (GSNO) and S-nitroso-N-acetylcysteine (NacySNO) at pH 6.4 (PBS/HCl) and 7.4 (PBS). Irradiation of S-nitrosothiol with light (lambda = 355 nm followed by absorption spectroscopy) resulted in the homolytic decomposition of NacySNO and GSNO to generate radicals (GS· and NacyS·) and NO. The release of NO from donor compounds measured with an ISO-Nometer apparatus was larger at pH 7.4 than pH 6.4. NacySNO was also incorporated into dipalmitoyl-phosphatidylcholine liposomes in the presence and absence of zinc phthalocyanine (ZnPC), a well-known photosensitizer useful for photodynamic therapy. Liposomes are usually used as carriers for hydrophobic... Tipo: Info:eu-repo/semantics/article Palavras-chave: S-nitrosothiols; Nitric oxide; Zinc phthalocyanine; Liposomes; Photodynamic therapy. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500005 Nitric oxide releasing-dendrimers: an overview BJPS Roveda Júnior,Antonio Carlos; Franco,Douglas Wagner. Platforms able to storage, release or scavenge NO in a controlled and specific manner is interesting for biological applications. Among the possible matrices for these purposes, dendrimers are excellent candidates for that. These molecules have been used as drug delivery systems and exhibit interesting properties, like the possibility to perform chemical modifications on dendrimers surface, the capacity of storage high concentrations of compounds of interest in the same molecule and the ability to improve the solubility and the biocompatibility of the compounds bonded to it. This review emphasizes the recent progress in the development and in the biological applications of different NO-releasing dendrimers and the nitric oxide release pathways in these... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dendrimer; Nitric oxide; Nitrosyl complexes; Diazeniumdiolate; Nitrosothiol. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700002 Nitric oxide synthase activity in tissues of the blowfly Chrysomya megacephala: Fabricius, 1794 Biocell Faraldo,A. C.; Sá-Nunes,A; Faccioli,L. H.; Del Bel,E. A.; Lello,E. Although insects lack the adaptive immune response of the mammalians, they manifest effective innate immune responses, which include both cellular and humoral components. Cellular responses are mediated by hemocytes, and humoral responses include the activation of proteolytic cascades that initiate many events, including NO production. In mammals, nitric oxide synthases (NOSs) are also present in the endothelium, the brain, the adrenal glands, and the platelets. Studies on the distribution of NO-producing systems in invertebrates have revealed functional similarities between NOS in this group and vertebrates. We attempted to localize NOS activity in tissues of naïve (UIL), yeast-injected (YIL), and saline-injected (SIL) larvae of the blowfly Chrysomya... Tipo: Info:eu-repo/semantics/article Palavras-chave: NO synthase; Nitric oxide; NADPH-diaphorase; Chrysomya megacephala; Blowfly; Tissues. Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000200002 Nitric oxide synthase blockade and body fluid volumes BJMBR Balaszczuk,A.M.; Tomat,A.; Bellucci,S.; Fellet,A.; Arranz,C.. The influence of chronic nitric oxide synthase inhibition with N G-nitro-L-arginine methyl ester (L-NAME) on body fluid distribution was studied in male Wistar rats weighing 260-340 g. Extracellular, interstitial and intracellular spaces, as well as plasma volume were measured after a three-week treatment with L-NAME (~70 mg/kg per 24 h in drinking water). An increase in extracellular space (16.1 ± 1.1 vs 13.7 ± 0.6 ml/100 g in control group, N = 12, P<0.01), interstitial space (14.0 ± 0.9 vs 9.7 ± 0.6 ml/100 g in control group, P<0.001) and total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P<0.001) was observed in the L-NAME group (N = 8). Plasma volume was lower in L-NAME-treated rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1... Tipo: Info:eu-repo/semantics/other Palavras-chave: Nitric oxide; Kidney; Heart; Body fluid; Hypertension; Extracellular space; Intracellular space; L-NAME. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100019 Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds BJMBR Pereira,A.C.; Paulo,M.; Araújo,A.V.; Rodrigues,G.J.; Bendhack,L.M.. During three decades, an enormous number of studies have demonstrated the critical role of nitric oxide (NO) as a second messenger engaged in the activation of many systems including vascular smooth muscle relaxation. The underlying cellular mechanisms involved in vasodilatation are essentially due to soluble guanylyl-cyclase (sGC) modulation in the cytoplasm of vascular smooth cells. sGC activation culminates in cyclic GMP (cGMP) production, which in turn leads to protein kinase G (PKG) activation. NO binds to the sGC heme moiety, thereby activating this enzyme. Activation of the NO-sGC-cGMP-PKG pathway entails Ca2+ signaling reduction and vasodilatation. Endothelium dysfunction leads to decreased production or bioavailability of endogenous NO that could... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Vasodilatation; Ruthenium complex; NO-synthase; Resistance artery; Conduit vessel. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900017 Nitro-fatty acids: novel anti-inflammatory lipid mediators BJMBR Rubbo,H.. Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases. Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitro-fatty acids; Antioxidants; Nitric oxide; Inflammation. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000900728 NO AND N2O FLUXES FROM A BELGIAN FOREST AFFECTED BY ELEVATED NITROGEN DEPOSITION Gayana Botánica Boeckx,Pascal; Vervaet,Hilde; Cleemput,Oswald van. Nitrous oxide (N2O) and nitric oxide (NO) are important atmospheric trace gases, and soils (including forest soils) are a substantial source of both gases. In forests subjected to elevated N deposition these emissions are considered as indirect emissions from agricultural N sources (mainly NH3) or combustion (e.g. NOx from traffic). However, knowledge about N2O and NO exchange between forests and the atmosphere is scarce. The aim of this study was to determine N2O and NO emission rates from a deciduous forest in Belgium, receiving a high N-deposition (ca. 40 kg N ha-1 yr-1). In April 2000, the NO emission from the forested location was 17.3 (± 1.2) and 17.05 (± 0.7) ng NO-N m-2 s-1, respectively, for the soil including the organic layer and the mineral... Tipo: Journal article Palavras-chave: Emission; Forest soil; Nitrogen; Cycling; Nitric oxide; Nitrous oxide. Ano: 2005 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-66432005000200003 Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities BJMBR Petit,C.; Bernardes-Genisson,V.; Hoffmann,P.; Souchard,J.-P.; Labidalle,S.. Novel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(MGD)2], revealing the formation of the complex [Fe(II)(MGD)2(NO)]. Furthermore, tests based on cytochrome c reduction were performed in order to study the ability of each phenolic disulfide, the final organic decomposition product of S-nitrosothiols, to trap superoxide radical anion (O2-). This study revealed a high reactivity of 1b and 3b towards O2-. For these two compounds, the respective inhibitory concentration (IC) 50 values were 92 µM and 43 µM. Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; S-nitrosothiols (thionitrites); Antioxidant; Peroxynitrite. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100011 Oral administration of L-arginine decreases blood pressure and increases renal excretion of sodium and water in renovascular hypertensive rats BJMBR Gouvêa,S.A.; Moysés,M.R.; Bissoli,N.S.; Pires,J.G.P.; Cabral,A.M.; Abreu,G.R.. The two-kidney, one-clip renovascular (2K1C) hypertension model is characterized by a reduction in renal flow on the clipped artery that activates the renin-angiotensin system. Endothelium dysfunction, including diminished nitric oxide production, is also believed to play a role in the pathophysiology of this model. Some studies have shown an effect of L-arginine (L-Arg, a nitric oxide precursor) on hypertension. In the present study we determined the ability of L-Arg (7 days of treatment) to reduce blood pressure and alter renal excretions of water, Na+ and K+ in a model of 2K1C-induced hypertension. Under ether anesthesia, male Wistar rats (150-170 g) had a silver clip (0.20 mm) placed around the left renal artery to produce the 2K1C renovascular... Tipo: Info:eu-repo/semantics/article Palavras-chave: L-arginine; Nitric oxide; Renovascular hypertension; Sodium excretion; Renal physiology; Blood pressure. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700017 Oxidative stress may explain how hypertension is maintained by normal levels of angiotensin II BJMBR Romero,J.C.; Reckelhoff,J.F.. It is well known that essential hypertension evolves in most patients with "near normal" levels of plasma renin activity. However, these levels appear to be responsible for the high levels of arterial pressure because they are normalized by the administration of angiotensin II converting inhibitors or angiotensin receptor antagonist. In experimental animals, hypertension can be induced by the continuous intravenous infusion of small doses of angiotensin II that are not sufficient to evoke an immediate pressor response. However, this condition resembles the characteristics of essential hypertension because the high levels of blood pressure exist with normal plasma levels of angiotensin II. It is suggested that small amounts of angiotensin whose plasma... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Isoprostanes; Peroxynitrites; Essential hypertension. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600006 Pancreatic nitric oxide and oxygen free radicals in the early stages of streptozotocin-induced diabetes mellitus in the rat BJMBR González,E.; Roselló-Catafau,J.; Jawerbaum,A.; Sinner,D.; Pustovrh,C.; Vela,J.; White,V.; Xaus,C.; Peralta,C.; Gimeno,M.. The objective of the present study was to explore the regulatory mechanisms of free radicals during streptozotocin (STZ)-induced pancreatic damage, which may involve nitric oxide (NO) production as a modulator of cellular oxidative stress. Removal of oxygen species by incubating pancreatic tissues in the presence of polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) (1 U/ml) produced a decrease in nitrite levels (42%) and NO synthase (NOS) activity (50%) in diabetic but not in control samples. When NO production was blocked by N G-monomethyl-L-arginine (L-NMMA) (600 µM), SOD activity increased (15.21 ± 1.23 vs 24.40 ± 2.01 U/mg dry weight). The increase was abolished when the NO donor, spermine nonoate, was added to the incubating medium (13.2 ±... Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptozotocin diabetes; Pancreas; Oxidative stress; Nitric oxide. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100012 Participation of nitric oxide in the nucleus isthmi in CO2-drive to breathing in toads BJMBR Gargaglioni,L.H.; Branco,L.G.S.. The nucleus isthmi (NI) is a mesencephalic structure of the amphibian brain. It has been reported that NI plays an important role in integration of CO2 chemoreceptor information and glutamate is probably involved in this function. However, very little is known about the mechanisms involved. Recently, it has been shown that nitric oxide synthase (NOS) is expressed in the brain of the frog. Thus the gas nitric oxide (NO) may be involved in different functions in the brain of amphibians and may act as a neurotransmitter or neuromodulator. We tested the hypothesis that NO plays a role in CO2-drive to breathing, specifically in the NI comparing pulmonary ventilation, breathing frequency and tidal volume, after microinjecting 100 nmol/0.5 µl of L-NAME (a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Amphibian; Hypercapnia; Ventilation; Nucleus isthmi; Toad; CO2; L-NAME. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100010 Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats BJMBR Barbosa,A.L.R.; Pinheiro,C.A.; Oliveira,G.J.; Torres,J.N.L.; Moraes,M.O.; Ribeiro,R.A.; Vale,M.L.; Souza,M.H.L.P.. Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K+ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investigate a possible involvement of the NO/cGMP/K+ATP pathway in antinociception induced in Walker 256 tumor-bearing male Wistar rats (180-220 g). The groups consisted of 5-6 animals. Mechanical inflammatory hypernociception was evaluated using an electronic version of the von Frey test. Walker tumor (4th and 7th day post-implantation) reduced prostaglandin E2- (PGE2, 400 ng/paw; 50 µL; intraplantar injection)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Walker 246 tumor-bearing rats; Hypernociception; Nitric oxide; Carrageenan. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600009 Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle BJMBR Leite,L.N.; Gonzaga,N.A.; Tirapelli,D.P.C.; Tirapelli,L.F.; Tirapelli,C.R.. The aim of the present study was to determine the mechanisms underlying the relaxant effect of adrenomedullin (AM) in rat cavernosal smooth muscle (CSM) and the expression of AM system components in this tissue. Functional assays using standard muscle bath procedures were performed in CSM isolated from male Wistar rats. Protein and mRNA levels of pre-pro-AM, calcitonin receptor-like receptor (CRLR), and Subtypes 1, 2 and 3 of the receptor activity-modifying protein (RAMP) family were assessed by Western immunoblotting and quantitative real-time polymerase chain reaction, respectively. Nitrate and 6-keto-prostaglandin F1α (6-keto-PGF1α; a stable product of prostacyclin) levels were determined using commercially available kits. Protein and mRNA of AM, CRLR,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rat cavernosal smooth muscle; Adrenomedullin; Relaxation; Nitric oxide; Calcitonin receptor-like receptor. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001000876 Preeclampsia: from epidemiological observations to molecular mechanisms BJMBR López-Jaramillo,P.; Casas,J.P.; Serrano,N.. Preeclampsia is the main cause of maternal mortality and is associated with a five-fold increase in perinatal mortality in developing countries. In spite of this, the etiology of preeclampsia is unknown. The present article analyzes the contradictory results of the use of calcium supplementation in the prevention of preeclampsia, and tries to give an explanation of these results. The proposal of an integrative model to explain the clinical manifestations of preeclampsia is discussed. In this proposal we suggest that preeclampsia is caused by nutritional, environmental and genetic factors that lead to the creation of an imbalance between the free radicals nitric oxide, superoxide and peroxynitrate in the vascular endothelium. The adequate interpretation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Preeclampsia; Calcium supplementation; Nitric oxide; Infection; Inflammation; Oxidative stress; Endothelial dysfunction. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000001 Protective effect of N-acetylcysteine against oxygen radical-mediated coronary artery injury BJMBR Rodrigues,A.J.; Évora,P.R.B.; Schaff,H.V.. The present study investigated the protective effect of N-acetylcysteine (NAC) against oxygen radical-mediated coronary artery injury. Vascular contraction and relaxation were determined in canine coronary arteries immersed in Kreb's solution (95% O2-5% CO2), incubated or not with NAC (10 mM), and exposed to free radicals (FR) generated by xanthine oxidase (100 mU/ml) plus xanthine (0.1 mM). Rings not exposed to FR or NAC were used as controls. The arteries were contracted with 2.5 µM prostaglandin F2alpha. Subsequently, concentration-response curves for acetylcholine, calcium ionophore and sodium fluoride were obtained in the presence of 20 µM indomethacin. Concentration-response curves for bradykinin, calcium ionophore, sodium nitroprusside, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coronary arteries; N-acetylcysteine; Endothelium; Oxidative stress; Nitric oxide. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800012 Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice BJMBR Naviliat,M.; Gualco,G.; Cayota,A.; Radi,R.. Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess production of ·NO and oxidants leads to the generation of nitrogen dioxide (·NO2), a strong nitrating agent. Tyrosine nitration is a post-translational modification resulting from the addition of a nitro (-NO2) group to the ortho-position of tyrosine residues. Detection of protein 3-nitrotyrosine is regarded as a marker of nitro-oxidative stress and is observed in inflammatory processes. The formation and role of nitrating species in the control and myocardiopathy of T. cruzi infection remain to be studied. We investigated the levels of ·NO and protein 3-nitrotyrosine in the plasma of C3H and BALB/c mice and pharmacologically modulated their production during... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peroxynitrite; Nitric oxide; Nitrotyrosine; Free radicals; Trypanosoma cruzi; Chagas' disease. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200011 Purine nucleotides reduce superoxide production by nitric oxide synthase in a murine sepsis model BJMBR Barbeiro,H.V.; Barbeiro,D.F.; Debbas,V.; Souza,H.P.; Laurindo,F.R.; Velasco,I.T.; Soriano,F.G.. Sepsis involves a systemic inflammatory response of multiple endogenous mediators, resulting in many of the injurious and sometimes fatal physiological symptoms of the disease. This systemic activation leads to a compromised vascular response and endothelial dysfunction. Purine nucleotides interact with purinoceptors and initiate a variety of physiological processes that play an important role in maintaining cardiovascular function. The purpose of the present study was to investigate the effects of ATP on vascular function in a lipopolysaccharide (LPS) model of sepsis. LPS induced a significant increase in aortic superoxide production 16 h after injection. Addition of ATP to the organ bath incubation solution reduced superoxide production by the aortas of... Tipo: Info:eu-repo/semantics/article Palavras-chave: ATP; Endotoxin; Endothelium; Superoxide; Nitric oxide. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100009 Registros recuperados: 143 Primeira ... 1 2 3 4 5 6 7 8 ... Última

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